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Target
Endothelin-1 receptor
Ligand
BDBM50289111
Substrate
n/a
Meas. Tech.
ChEBML_65330
IC50
>1000±n/a nM
Citation
 Shibata, K; Yano, K; Tanaka, T; Matsuda, Y; Yamasaki, M Analogs of an endothelin antagonist RES-701-1: substitutions of C-terminal amino acid Bioorg Med Chem Lett 6:775-778 (1996)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_BOVIN | ET-A | Endothelin A receptor | Endothelin receptor ET-A | Endothelin-1 receptor
Type:
PROTEIN
Mol. Mass.:
48527.56
Organism:
Bos taurus
Description:
ChEMBL_65329
Residue:
427
Sequence:
METFWLRLSFWVALVGGVISDNPESYSTNLSIHVDSVATFHGTELSFVVTTHQPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFEQNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGAQHRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDTNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERSSHKDSIN
  
Inhibitor
Name:
BDBM50289111
Synonyms:
CHEMBL411057 | RES-701-1-C-terminal analogue
Type:
Small organic molecule
Emp. Form.:
C103H115N23O23
Mol. Mass.:
2043.1555
SMILES:
C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Structure:
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