Reaction Details Report a problem with these data
Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM50289140
Substrate
n/a
Meas. Tech.
ChEBML_210838
Ki
50±n/a nM
Citation
 Madge, DJ; Hazelwood, R; Iyer, R; Jones, HT; Salter, M Novel tryptophan dioxygenase inhibitors and combined tryptophan dioxygenase/5-HT reuptake inhibitors Bioorg Med Chem Lett 6:857-860 (1996)    Article 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_RAT | TO | TRPO | Tdo | Tdo2 | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase
Type:
PROTEIN
Mol. Mass.:
47856.01
Organism:
Rattus norvegicus
Description:
ChEMBL_210838
Residue:
406
Sequence:
MSGCPFSGNSVGYTLKNLSMEDNEEDGAQTGVNRASKGGLIYGDYLQLEKILNAQELQSEIKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVMTRMHRVVVIFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHYRDNFEGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPHGFNFWGKFEKNILKGLEEEFLKIQAKKDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGSKAGTGGSSGYYYLRSTVSDRYKVFVDLFNLSSYLVPRHWIPKMNPIIHKFLYTAEYSDSSYFSSDESD
  
Inhibitor
Name:
BDBM50289140
Synonyms:
5-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | CHEMBL168956
Type:
Small organic molecule
Emp. Form.:
C15H11FN2
Mol. Mass.:
238.2596
SMILES:
Fc1ccc2[nH]cc(\C=C\c3cccnc3)c2c1
Structure:
Search PDB for entries with ligand similarity: