Reaction Details Report a problem with these data
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50403612
Substrate
n/a
Meas. Tech.
ChEBML_205049
Ki
2000±n/a nM
Citation
 Abell, AD; Brandt, M; Levy, MA; Holt, DA The preparation and evaluation of (+/-)-trans-1-Diazo-8-methoxy-4a-methyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-2-one as an inhibitor of human type-1 steroid 5α-reductase Bioorg Med Chem Lett 6:883-884 (1996)    Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50403612
Synonyms:
CHEMBL167774
Type:
Small organic molecule
Emp. Form.:
C16H18N2O2
Mol. Mass.:
270.3263
SMILES:
COc1cccc2c1CC[C@H]1[C-]([N+]#N)C(=O)CC[C@]21C
Structure:
Search PDB for entries with ligand similarity: