Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM50289951
Substrate
n/a
Meas. Tech.
ChEBML_158973
IC50
1300±n/a nM
Citation
 Abood, NA; Schretzman, LA; Flynn, DL; Houseman, KA; Wittwer, AJ; Dilworth, VM; Hippenmeyer, PJ; Holwerda, BC Inhibition of human cytomegalovirus protease by benzoxazinones and evidence of antiviral activity in cell culture Bioorg Med Chem Lett 7:2105-2108 (1997)    Article 
Target
Name:
Genome polyprotein
Synonyms:
Human rhinovirus A protease | Human rhinovirus B 3A protease
Type:
PROTEIN
Mol. Mass.:
44361.04
Organism:
Human rhinovirus B
Description:
ChEMBL_158953
Residue:
401
Sequence:
AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMSAIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIANIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVITTGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDRNEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQTIHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
  
Inhibitor
Name:
BDBM50289951
Synonyms:
CHEMBL63952 | [5-Methyl-4-oxo-2-(1-phenyl-ethylamino)-4H-benzo[d][1,3]oxazin-6-yl]-carbamic acid tert-butyl ester
Type:
Small organic molecule
Emp. Form.:
C22H25N3O4
Mol. Mass.:
395.4516
SMILES:
C[C@@H](Nc1nc2ccc(NC(=O)OC(C)(C)C)c(C)c2c(=O)o1)c1ccccc1
Structure:
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