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Target
Neutrophil collagenase
Ligand
BDBM50291441
Substrate
n/a
Meas. Tech.
ChEMBL_105206 (CHEMBL713845)
IC50
4100±n/a nM
Citation
 Baxter, AD; Bird, J; Bhogal, R; Massil, T; Minton, KJ; Montana, J; Owen, DA A novel series of matrix metalloproteinase inhibitors for the treatment of inflammatory disorders Bioorg Med Chem Lett 7:897-902 (1997)    Article 
Target
Name:
Neutrophil collagenase
Synonyms:
MMP8_RAT | Matrix metalloproteinase 8 | Mmp8
Type:
PROTEIN
Mol. Mass.:
53278.33
Organism:
Rattus norvegicus
Description:
ChEMBL_12591
Residue:
466
Sequence:
MLHLKTLPFLFFFHTQLATALPVPPEHLEEKNMKTAENYLRKFYHLPSNQFRSARNATMIAEKLKEMQRFFGLPETGKPDAATIEIMEKPRCGVPDSGDFLLTPGSPKWTHTNLTYRIINHTPQMSKAEVKTEIEKAFKIWSVPSTLTFTETLEGEADINIAFVSRDHGDNSPFDGPNGILAHAFQPGRGIGGDAHFDSEETWTQDSKNYNLFLVAAHEFGHSLGLSHSTDPGALMYPNYAYREPSTYSLPQDDINGIQTIYGPSDNPVQPTGPSTPTACDPHLRFDAATTLRGEIYFFKDKYFWRRHPQLRTVDLNFISLFWPFLPNGLQAAYEDFDRDLVFLFKGRQYWALSAYDLQQGYPRDISNYGFPRSVQAIDAAVSYNGKTYFFVNNQCWRYDNQRRSMDPGYPTSIASVFPGINCRIDAVFQQDSFFLFFSGPQYFAFNLVSRRVTRVARSNLWLNCP
  
Inhibitor
Name:
BDBM50291441
Synonyms:
(S)-3-Hydroxy-2-(2-mercapto-acetylamino)-N-((S)-1-methylcarbamoyl-2-phenyl-ethyl)-butyramide | CHEMBL172892
Type:
Small organic molecule
Emp. Form.:
C16H23N3O4S
Mol. Mass.:
353.437
SMILES:
CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CS)C(C)O
Structure:
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