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Target
Neutrophil elastase
Ligand
BDBM50291760
Substrate
n/a
Meas. Tech.
ChEMBL_63835 (CHEMBL872885)
Ki
0.940000±n/a nM
Citation
 Krantz, A; Spencer, RW; Tam, TF; Thomas, E; Copp, LJ. Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation. J Med Chem 30:589-591 (1987) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50291760
Synonyms:
5-Ethyl-2-isopropylamino-benzo[d][1,3]oxazin-4-one | CHEMBL145550
Type:
Small organic molecule
Emp. Form.:
C13H16N2O2
Mol. Mass.:
232.2783
SMILES:
CCc1cccc2nc(NC(C)C)oc(=O)c12
Structure:
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