Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50292355
Substrate
n/a
Meas. Tech.
ChEMBL_502637 (CHEMBL989312)
IC50
>91000±n/a nM
Citation
 Haraguchi, H; Ohmi, I; Sakai, S; Fukuda, A; Toihara, Y; Fujimoto, T; Okamura, N; Yagi, A Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes. J Nat Prod 59:443-5 (1996) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR_PIG | ALR2 | AR | Aldose reductase
Type:
PROTEIN
Mol. Mass.:
35865.31
Organism:
Sus scrofa
Description:
ChEMBL_502637
Residue:
316
Sequence:
MASHLVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEKLQGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCALMSCASHKDYPFHEEY
  
Inhibitor
Name:
BDBM50292355
Synonyms:
CHEMBL457148 | Rhamnazin
Type:
Small organic molecule
Emp. Form.:
C17H14O7
Mol. Mass.:
330.2889
SMILES:
COc1cc(O)c2c(c1)oc(-c1ccc(O)c(OC)c1)c(O)c2=O
Structure:
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