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Target
Adenosine receptor A3
Ligand
BDBM50293031
Substrate
n/a
Meas. Tech.
ChEMBL_518789 (CHEMBL960425)
EC50
31±n/a nM
Citation
 Heitman, LH; Göblyös, A; Zweemer, AM; Bakker, R; Mulder-Krieger, T; van Veldhoven, JP; de Vries, H; Brussee, J; Ijzerman, AP A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor. J Med Chem 52:926-31 (2009) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50293031
Synonyms:
2-chloro-N6-(3-iodobenzyl)-5'-N-methylcarbamoyladenosine | 2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide | CHEMBL515442
Type:
Small organic molecule
Emp. Form.:
C19H20ClIN6O5
Mol. Mass.:
574.757
SMILES:
CNC(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12 |r|
Structure:
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