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Target
Luciferin 4-monooxygenase
Ligand
BDBM50293105
Substrate
n/a
Meas. Tech.
ChEMBL_514921 (CHEMBL972647)
IC50
>50000±n/a nM
Citation
 Auld, DS; Zhang, YQ; Southall, NT; Rai, G; Landsman, M; MacLure, J; Langevin, D; Thomas, CJ; Austin, CP; Inglese, J A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. J Med Chem 52:1450-8 (2010) [PubMed]  Article 
Target
Name:
Luciferin 4-monooxygenase
Synonyms:
LUCI_PHOPE
Type:
PROTEIN
Mol. Mass.:
60658.88
Organism:
Photuris pennsylvanica
Description:
ChEMBL_514919
Residue:
545
Sequence:
MEDKNILYGPEPFHPLADGTAGEQMFYALSRYADISGCIALTNAHTKENVLYEEFLKLSCRLAESFKKYGLKQNDTIAVCSENGLQFFLPLIASLYLGIIAAPVSDKYIERELIHSLGIVKPRIIFCSKNTFQKVLNVKSKLKYVETIIILDLNEDLGGYQCLNNFISQNSDINLDVKKFKPNSFNRDDQVALVMFSSGTTGVSKGVMLTHKNIVARFSHCKDPTFGNAINPTTAILTVIPFHHGFGMTTTLGYFTCGFRVALMHTFEEKLFLQSLQDYKVESTLLVPTLMAFFPKSALVEKYDLSHLKEIASGGAPLSKEIGEMVKKRFKLNFVRQGYGLTETTSAVLITPDTDVRPGSTGKIVPFHAVKVVDPTTGKILGPNETGELYFKGDMIMKSYYNNEEATKAIINKDGWLRSGDIAYYDNDGHFYIVDRLKSLIKYKGYQVAPAEIEGILLQHPYIVDAGVTGIPDEAAGELPAAGVVVQTGKYLNEQIVQNFVSSQVSTAKWLRGGVKFLDEIPKGSTGKIDRKVLRQMFEKHKSKL
  
Inhibitor
Name:
BDBM50293105
Synonyms:
2-(4-Methoxyphenyl)benzo[d]thiazole | CHEMBL460508
Type:
Small organic molecule
Emp. Form.:
C14H11NOS
Mol. Mass.:
241.308
SMILES:
COc1ccc(cc1)-c1nc2ccccc2s1
Structure:
Search PDB for entries with ligand similarity: