Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM50293236
Substrate
n/a
Meas. Tech.
ChEMBL_497219 (CHEMBL1006172)
IC50
8±n/a nM
Citation
 Aissaoui, H; Koberstein, R; Zumbrunn, C; Gatfield, J; Brisbare-Roch, C; Jenck, F; Treiber, A; Boss, C N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists. Bioorg Med Chem Lett 18:5729-33 (2009) [PubMed]  Article 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM50293236
Synonyms:
2-(N-(6-chloro-3-methylbenzo[d]isothiazol-5-yl)-3,4-dimethoxyphenylsulfonamido)-N-ethyl-N-(6-methylpyridin-2-yl)acetamide | CHEMBL526837
Type:
Small organic molecule
Emp. Form.:
C26H27ClN4O5S2
Mol. Mass.:
575.099
SMILES:
CCN(C(=O)CN(c1cc2c(C)nsc2cc1Cl)S(=O)(=O)c1ccc(OC)c(OC)c1)c1cccc(C)n1
Structure:
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