Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50293468
Substrate
n/a
Meas. Tech.
ChEMBL_570542 (CHEMBL1026914)
Ki
2334±n/a nM
Citation
 Abu-Hammad, A; Zalloum, WA; Zalloum, H; Abu-Sheikha, G; Taha, MO Homology modeling of MCH1 receptor and validation by docking/scoring and protein-aligned CoMFA. Eur J Med Chem 44:2583-96 (2009) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50293468
Synonyms:
4-(1-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)ethyl)-N-((S)-1-(4-bromophenyl)ethyl)benzamide | CHEMBL561148
Type:
Small organic molecule
Emp. Form.:
C29H32BrN3O3
Mol. Mass.:
550.487
SMILES:
C[C@H](NC(=O)c1ccc(cc1)C(C)N1CCN(Cc2ccc3OCOc3c2)CC1)c1ccc(Br)cc1 |r|
Structure:
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