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Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50293835
Substrate
n/a
Meas. Tech.
ChEMBL_572371 (CHEMBL1035272)
pH
7.4±n/a
Ki
19000±n/a nM
Comments
extracted
Citation
 Keough, DT; Hocková, D; Holý, A; Naesens, LM; Skinner-Adams, TS; Jersey, J; Guddat, LW Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. J Med Chem 52:4391-9 (2009) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM50293835
Synonyms:
(R)-5-(2-Amino-6-oxo-1,6,7,8-tetrahydro-purin-9-ylmethyl)-2-oxo-2lambda*5*-[1,4,2]dioxaphosphinan-2-ol anion | CHEMBL560829
Type:
Small organic molecule
Emp. Form.:
C9H14N5O5P
Mol. Mass.:
303.2117
SMILES:
Nc1nc2N(C[C@@H]3COP(O)(=O)CO3)CNc2c(=O)[nH]1 |r|
Structure:
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