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Target
Carbonic anhydrase 2
Ligand
BDBM50294018
Substrate
n/a
Meas. Tech.
ChEMBL_572881 (CHEMBL1034441)
Ki
6.9±n/a nM
Citation
 Nasr, G; Petit, E; Vullo, D; Winum, JY; Supuran, CT; Barboiu, M Carbonic anhydrase-encoded dynamic constitutional libraries: toward the discovery of isozyme-specific inhibitors. J Med Chem 52:4853-9 (2009) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50294018
Synonyms:
CHEMBL549331 | N-(2-Fluorobenzyl)(4-sulphonamide phenyl)ethanamine
Type:
Small organic molecule
Emp. Form.:
C15H17FN2O2S
Mol. Mass.:
308.371
SMILES:
NS(=O)(=O)c1ccc(CCNCc2ccccc2F)cc1
Structure:
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