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Target
Polyamine oxidase 1
Ligand
BDBM50294097
Substrate
n/a
Meas. Tech.
ChEMBL_570655 (CHEMBL1033595)
pH
6.5±n/a
Ki
1720±n/a nM
Comments
extracted
Citation
 Manetti, F; Cona, A; Angeli, L; Mugnaini, C; Raffi, F; Capone, C; Dreassi, E; Zizzari, AT; Tisi, A; Federico, R; Botta, M Synthesis and biological evaluation of guanidino compounds endowed with subnanomolar affinity as competitive inhibitors of maize polyamine oxidase. J Med Chem 52:4774-85 (2009) [PubMed]  Article 
Target
Name:
Polyamine oxidase 1
Synonyms:
MPAO | MPAO1 | PAO | PAO1_MAIZE | Polyamine oxidase
Type:
PROTEIN
Mol. Mass.:
56339.65
Organism:
Zea mays
Description:
ChEMBL_570655
Residue:
500
Sequence:
MSSSPSFGLLAVAALLLALSLAQHGSLAATVGPRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWVEGVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADSVEEMGEKLSATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMCKYHVQGKYD
  
Inhibitor
Name:
BDBM50294097
Synonyms:
CHEMBL550629 | N1-(5-Aminopentyl)-N3-(cyclohexylethyl)guanidine bis(trifluoroacetate)
Type:
Small organic molecule
Emp. Form.:
C14H30N4
Mol. Mass.:
254.4148
SMILES:
NCCCCCN=C(N)NCCC1CCCCC1 |w:6.5|
Structure:
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