Reaction Details Report a problem with these data
Target
Polyamine oxidase 1
Ligand
BDBM50294104
Substrate
n/a
Meas. Tech.
ChEMBL_570655 (CHEMBL1033595)
pH
6.5±n/a
Ki
3±n/a nM
Comments
extracted
Citation
 Manetti, F; Cona, A; Angeli, L; Mugnaini, C; Raffi, F; Capone, C; Dreassi, E; Zizzari, AT; Tisi, A; Federico, R; Botta, M Synthesis and biological evaluation of guanidino compounds endowed with subnanomolar affinity as competitive inhibitors of maize polyamine oxidase. J Med Chem 52:4774-85 (2009) [PubMed]  Article 
Target
Name:
Polyamine oxidase 1
Synonyms:
MPAO | MPAO1 | PAO | PAO1_MAIZE | Polyamine oxidase
Type:
PROTEIN
Mol. Mass.:
56339.65
Organism:
Zea mays
Description:
ChEMBL_570655
Residue:
500
Sequence:
MSSSPSFGLLAVAALLLALSLAQHGSLAATVGPRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWVEGVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADSVEEMGEKLSATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMCKYHVQGKYD
  
Inhibitor
Name:
BDBM50294104
Synonyms:
1-(Guanidino)-17-(N1-(gamma,gamma-dimethylallyl)guanidino)-9-azaheptadecane tris(trifluoroacetate) | CHEMBL560699 | N-(8-{8-[N'-(3-Methyl-but-2-enyl)-guanidino]-octylamino}-octyl)-guanidine
Type:
Small organic molecule
Emp. Form.:
C23H49N7
Mol. Mass.:
423.6821
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#7]-[#6](-[#7])=[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7] |w:8.8|
Structure:
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