Reaction Details Report a problem with these data
Target
Dihydrolipoyl dehydrogenase, mitochondrial
Ligand
BDBM50241461
Substrate
n/a
Meas. Tech.
ChEMBL_575051 (CHEMBL1031236)
pH
7.3±n/a
IC50
>1000000±n/a nM
Comments
extracted
Citation
 Buchholz, K; Schirmer, RH; Eubel, JK; Akoachere, MB; Dandekar, T; Becker, K; Gromer, S Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum. Antimicrob Agents Chemother 52:183-91 (2007) [PubMed]  Article 
Target
Name:
Dihydrolipoyl dehydrogenase, mitochondrial
Synonyms:
DLD | DLDH_PIG | Dihydrolipoamide dehydrogenase | LAD
Type:
PROTEIN
Mol. Mass.:
54192.22
Organism:
Sus scrofa
Description:
ChEMBL_575051
Residue:
509
Sequence:
MQSWSRVYCTLAKRGHFNRIAHGLQGVSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLEKMMEQKSNAVKALTGGIAHLFKQNKVVRVNGYGKITGKNQVTATKADGSTEVINTKNILIATGSEVTPFPGITIDEDTVVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVELLGHVGGIGIDMEVSKNFQRILQKQGFKFKLNTKVIGATKKSDGNIDVSIEAASGGKAEVITCDVLLVCIGRRPFTQNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHIIGPGAGEMINEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKAINF
  
Inhibitor
Name:
BDBM50241461
Synonyms:
3,7-bis(dimethylamino)phenothiazin-5-ium chloride | Basic Blue 9 | CHEMBL405110 | Methylenblau | Methylene Blue anhydrous | Methylene blue | Methylene blue (10) | SAMPL5, CBC-G10 | azul de metileno | bleu de methylene | cid_6099 | methylthioninium chloride
Type:
Small organic molecule
Emp. Form.:
C16H18N3S
Mol. Mass.:
284.399
SMILES:
CN(C)c1ccc2nc3ccc(cc3sc2c1)=[N+](C)C |(17.73,-40.24,;19.06,-41.01,;19.06,-42.55,;20.39,-40.24,;20.4,-38.7,;21.73,-37.93,;23.06,-38.69,;24.39,-37.91,;25.73,-38.69,;27.06,-37.93,;28.39,-38.69,;28.39,-40.23,;27.06,-41,;25.73,-40.23,;24.39,-41.01,;23.06,-40.24,;21.73,-41.01,;29.73,-41,;29.73,-42.54,;31.06,-40.23,)|
Structure:
Search PDB for entries with ligand similarity: