Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50294666
Substrate
n/a
Meas. Tech.
ChEMBL_575807 (CHEMBL1024508)
Ki
90.2±n/a nM
Citation
 Pal, S; Choi, WJ; Choe, SA; Heller, CL; Gao, ZG; Chinn, M; Jacobson, KA; Hou, X; Lee, SK; Kim, HO; Jeong, LS Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists. Bioorg Med Chem 17:3733-8 (2009) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50294666
Synonyms:
(2R,3R,4R)-2-(6-(3-Iodobenzylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol | CHEMBL549352
Type:
Small organic molecule
Emp. Form.:
C16H16IN5O3
Mol. Mass.:
453.2344
SMILES:
O[C@@H]1CO[C@H]([C@@H]1O)n1cnc2c(NCc3cccc(I)c3)ncnc12 |r|
Structure:
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