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Target
Proto-oncogene Wnt-3
Ligand
BDBM50294831
Substrate
n/a
Meas. Tech.
ChEMBL_576549 (CHEMBL1032002)
EC50
>25000±n/a nM
Citation
 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett 19:3825-7 (2009) [PubMed]  Article 
Target
Name:
Proto-oncogene Wnt-3
Synonyms:
INT4 | Proto-oncogene protein Wnt-3 | WNT3 | WNT3_HUMAN
Type:
PROTEIN
Mol. Mass.:
39653.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_576549
Residue:
355
Sequence:
MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK
  
Inhibitor
Name:
BDBM50294831
Synonyms:
4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-ylmethyl)-cyclohexanecarboxylic acid quinolin-8-ylamide | CHEMBL552252
Type:
Small organic molecule
Emp. Form.:
C26H27N3O3
Mol. Mass.:
429.5109
SMILES:
O=C(Nc1cccc2cccnc12)[C@H]1CC[C@H](CN2C(=O)[C@H]3[C@@H]4C[C@@H](C=C4)[C@H]3C2=O)CC1 |r,wU:22.24,24.25,13.14,wD:16.18,21.22,27.31,c:27,(26.78,-20.85,;25.44,-21.6,;25.42,-23.14,;26.74,-23.93,;28.09,-23.18,;29.42,-23.97,;29.4,-25.51,;28.06,-26.27,;28.04,-27.8,;26.7,-28.56,;25.37,-27.78,;25.39,-26.23,;26.73,-25.48,;24.11,-20.82,;22.78,-21.57,;21.45,-20.79,;21.47,-19.24,;20.15,-18.45,;18.61,-18.45,;17.71,-17.22,;18.18,-15.75,;16.24,-17.69,;14.92,-16.92,;15.3,-18.41,;14.89,-19.89,;13.58,-19.22,;13.58,-17.68,;16.24,-19.23,;17.7,-19.71,;18.18,-21.18,;22.82,-18.49,;24.14,-19.28,)|
Structure:
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