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Target
Thyroid hormone receptor alpha
Ligand
BDBM50106183
Substrate
n/a
Meas. Tech.
ChEMBL_577230 (CHEMBL1034537)
IC50
9200±n/a nM
Citation
 Hwang, JY; Arnold, LA; Zhu, F; Kosinski, A; Mangano, TJ; Setola, V; Roth, BL; Guy, RK Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. J Med Chem 52:3892-901 (2009) [PubMed]  Article 
Target
Name:
Thyroid hormone receptor alpha
Synonyms:
C-erbA-alpha | EAR-7 | EAR7 | ERBA1 | NR1A1 | Nuclear receptor subfamily 1 group A member 1 | THA_HUMAN | THRA | THRA1 | THRA2 | Thyroid Hormone Receptor (TR-alpha) | Thyroid hormone receptor | Thyroid hormone receptor alpha | Thyroid hormone receptor apha | c-erbA-1
Type:
Receptor
Mol. Mass.:
54818.00
Organism:
Homo sapiens (Human)
Description:
Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRalpha 1.
Residue:
490
Sequence:
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVCEDLAGNAASP
  
Inhibitor
Name:
BDBM50106183
Synonyms:
1-(4-(Hexyloxy)phenyl)-3-(piperidin-1-yl)propan-1-one | 1-(4-Hexyloxy-phenyl)-3-piperidin-1-yl-propan-1-one | CHEMBL121893
Type:
Small organic molecule
Emp. Form.:
C20H31NO2
Mol. Mass.:
317.4656
SMILES:
CCCCCCOc1ccc(cc1)C(=O)CCN1CCCCC1
Structure:
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