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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50295053
Substrate
n/a
Meas. Tech.
ChEMBL_574192 (CHEMBL1060393)
Ki
3.02±n/a nM
Citation
 Zhou, D; Stack, GP; Lo, J; Failli, AA; Evrard, DA; Harrison, BL; Hatzenbuhler, NT; Tran, M; Croce, S; Yi, S; Golembieski, J; Hornby, GA; Lai, M; Lin, Q; Schechter, LE; Smith, DL; Shilling, AD; Huselton, C; Mitchell, P; Beyer, CE; Andree, TH Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists. J Med Chem 52:4955-9 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50295053
Synonyms:
(S)-2-((4-(1H-Indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)-methyl)-8-methyl-2,3-dihydro-[1,4]dioxino-[2,3-f]quinoline | CHEMBL562248
Type:
Small organic molecule
Emp. Form.:
C26H25N3O2
Mol. Mass.:
411.4956
SMILES:
Cc1ccc2c3O[C@@H](CN4CCC(=CC4)c4c[nH]c5ccccc45)COc3ccc2n1 |r,c:12|
Structure:
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