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Target
Cyclin-dependent kinase 5
Ligand
BDBM50295354
Substrate
n/a
Meas. Tech.
ChEMBL_578399 (CHEMBL1057955)
IC50
>10000±n/a nM
Citation
 Corbel, C; Haddoub, R; Guiffant, D; Lozach, O; Gueyrard, D; Lemoine, J; Ratin, M; Meijer, L; Bach, S; Goekjian, P Identification of potential cellular targets of aloisine A by affinity chromatography. Bioorg Med Chem 17:5572-82 (2009) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5
Synonyms:
CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Inhibitor
Name:
BDBM50295354
Synonyms:
2-(1-{2-[2-(2-Aminoethoxy)ethoxy]ethyl}-1H-[1,2,3]triazol-4-yl)-4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol | CHEMBL557499
Type:
Small organic molecule
Emp. Form.:
C24H31N7O3
Mol. Mass.:
465.548
SMILES:
CCCCc1c([nH]c2nccnc12)-c1ccc(O)c(c1)-c1cn(CCOCCOCCN)nn1
Structure:
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