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TargetMacrophage metalloelastase
LigandBDBM50295479
Substrate/Competitorn/a
Meas. Tech.ChEMBL_579113
IC50 72±n/a nM
Citation Li, WLi, JWu, YRancati, FVallese, SRaveglia, LWu, JHotchandani, RFuller, NCunningham, KMorgan, PFish, SKrykbaev, RXu, XTam, SGoldman, SJAbraham, WWilliams, CSypek, JMansour, TS Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma. J Med Chem52:5408-19 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Macrophage metalloelastase
Name:Macrophage metalloelastase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:53750.82
Organism:Rattus norvegicus
Description:ChEMBL_579113
Residue:465
Sequence:
MKFLLVLVLLVSLQVSACGAAPMNESEFAEWYLSRFFDYQGDRIPMTKTKTNRNLLEEKL
QEMQQFFGLEVTGQLDTSTLKIMHTSRCGVPDVQHLRAVPQRSRWMKRYLTYRIYNYTPD
MKRADVDYIFQKAFQVWSDVTPLRFRKIHKGEADITILFAFGDHGDFYDFDGKGGTLAHA
FYPGPGIQGDAHFDEAETWTKSFQGTNLFLVAVHELGHSLGLRHSNNPKSIMYPTYRYLH
PNTFRLSADDIHSIQSLYGAPVKNPSLTNPGSPPSTVCHQSLSFDAVTTVGDKIFFFKDW
FFWWRLPGSPATNITSISSMWPTIPSGIQAAYEIGGRNQLFLFKDEKYWLINNLVPEPHY
PRSIHSLGFPASVKKIDAAVFDPLRQKVYFFVDKQYWRYDVRQELMDAAYPKLISTHFPG
IRPKIDAVLYFKRHYYIFQGAYQLEYDPLLDRVTKTLSSTSWFGC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50295479
NameBDBM50295479
Synonyms:(S)-3-Methyl-2-(8-(2-oxooxazolidin-3-yl)dibenzo[b,d]furan-3-sulfonamido)butanoic Acid | CHEMBL550038
TypeSmall organic molecule
Emp. Form.C20H20N2O7S
Mol. Mass.432.447
SMILESCC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)N1CCOC1=O)C(O)=O |r|
Structure
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n/a