Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM50295796
Substrate
n/a
Meas. Tech.
ChEMBL_578167 (CHEMBL1060467)
EC50
22900±n/a nM
Citation
 Zhou, Y; Vu, K; Chen, Y; Pham, J; Brady, T; Liu, G; Chen, J; Nam, J; Murali Mohan Reddy, PS; Au, Q; Yoon, IS; Tremblay, MH; Yip, G; Cher, C; Zhang, B; Barber, JR; Ng, SC Chloro-oxime derivatives as novel small molecule chaperone amplifiers. Bioorg Med Chem Lett 19:3128-35 (2009) [PubMed]  Article 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1 | HSF1_HUMAN | HSTF1
Type:
PROTEIN
Mol. Mass.:
57244.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1512556
Residue:
529
Sequence:
MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
  
Inhibitor
Name:
BDBM50295796
Synonyms:
6-chloro-N-(2-hydroxy-3-(piperidin-1-yl)propoxy)benzo[d]oxazole-2-carbimidoyl chloride | CHEMBL562322
Type:
Small organic molecule
Emp. Form.:
C16H19Cl2N3O3
Mol. Mass.:
372.246
SMILES:
OC(CO\N=C(/Cl)c1nc2ccc(Cl)cc2o1)CN1CCCCC1
Structure:
Search PDB for entries with ligand similarity: