Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM50296055
Substrate
n/a
Meas. Tech.
ChEMBL_579378 (CHEMBL1063219)
EC50
20600±n/a nM
Citation
 Zhou, Y; Wei, L; Brady, TP; Murali Mohan Redddy, PS; Nguyen, T; Chen, J; Au, Q; Yoon, IS; Yip, G; Zhang, B; Barber, JR; Ng, SC Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives as novel small molecule chaperone amplifiers. Bioorg Med Chem Lett 19:4303-7 (2009) [PubMed]  Article 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1 | HSF1_HUMAN | HSTF1
Type:
PROTEIN
Mol. Mass.:
57244.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1512556
Residue:
529
Sequence:
MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
  
Inhibitor
Name:
BDBM50296055
Synonyms:
1-ethyl-6-methyl-3-(5-methylfuran-2-yl)-5,7-dioxo-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine 4-oxide | CHEMBL553924
Type:
Small organic molecule
Emp. Form.:
C13H13N5O4
Mol. Mass.:
303.2734
SMILES:
CCn1nc(-c2ccc(C)o2)[n+]([O-])c2c1nc(=O)n(C)c2=O
Structure:
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