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Target
Stearoyl-CoA desaturase
Ligand
BDBM50296533
Substrate
n/a
Meas. Tech.
ChEMBL_582073 (CHEMBL1060792)
IC50
3±n/a nM
Citation
 Uto, Y; Ogata, T; Harada, J; Kiyotsuka, Y; Ueno, Y; Miyazawa, Y; Kurata, H; Deguchi, T; Watanabe, N; Takagi, T; Wakimoto, S; Okuyama, R; Abe, M; Kurikawa, N; Kawamura, S; Yamato, M; Osumi, J Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide. Bioorg Med Chem Lett 19:4151-8 (2009) [PubMed]  Article 
Target
Name:
Stearoyl-CoA desaturase
Synonyms:
Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1
Type:
Enzyme
Mol. Mass.:
41537.27
Organism:
Homo sapiens (Human)
Description:
O00767
Residue:
359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
  
Inhibitor
Name:
BDBM50296533
Synonyms:
3-(4-methoxyphenyl)-N-(5-(3-(trifluoromethyl)benzyl)thiazol-2-yl)acrylamide | CHEMBL560271
Type:
Small organic molecule
Emp. Form.:
C21H17F3N2O2S
Mol. Mass.:
418.432
SMILES:
COc1ccc(\C=C\C(=O)Nc2ncc(Cc3cccc(c3)C(F)(F)F)s2)cc1
Structure:
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