Reaction Details Report a problem with these data
Target
Integrin alpha-2
Ligand
BDBM50296634
Substrate
n/a
Meas. Tech.
ChEMBL_582347 (CHEMBL1053411)
IC50
>100000±n/a nM
Citation
 Elliot, D; Henshaw, E; MacFaul, PA; Morley, AD; Newham, P; Oldham, K; Page, K; Rankine, N; Sharpe, P; Ting, A; Wood, CM Novel inhibitors of the alphavbeta3 integrin--lead identification strategy. Bioorg Med Chem Lett 19:4832-5 (2009) [PubMed]  Article 
Target
Name:
Integrin alpha-2
Synonyms:
CD49B | CD49b antigen | Collagen receptor | GPIa | ITA2_HUMAN | ITGA2 | Integrin alpha-2 precursor | Integrin alpha2 | Platelet membrane glycoprotein Ia | VLA-2 alpha chain
Type:
Single-pass type I membrane protein
Mol. Mass.:
129273.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
1181
Sequence:
MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPATQPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTIVQKTSHGHLIFPKQAFDQILQDRNHSSYLGYSVAAISTGESTHFVAGAPRANYTGQIVLYSVNENGNITVIQAHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEEGRVYLFTIKKGILGQHQFLEGPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKILGSDGAFRSHLQYFGRSLDGYGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEASFTPEKITLVNKNAQIILKLCFSAKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNMVVNQAQSCPEHIIYIQEPSDVVNSLDLRVDISLENPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQNLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHSFEDVGPKFIFSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQTSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPTGVIIGSIIAGILLLLALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS
  
Inhibitor
Name:
BDBM50296634
Synonyms:
(R)-3-(furan-3-carboxamido)-2-(2-methoxyphenylsulfonamido)propanoic acid | CHEMBL550395
Type:
Small organic molecule
Emp. Form.:
C15H16N2O7S
Mol. Mass.:
368.362
SMILES:
COc1ccccc1S(=O)(=O)N[C@H](CNC(=O)c1ccoc1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: