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Target
Neutrophil elastase
Ligand
BDBM50296837
Substrate
n/a
Meas. Tech.
ChEMBL_582553 (CHEMBL1061649)
IC50
850±n/a nM
Citation
 Shreder, KR; Cajica, J; Du, L; Fraser, A; Hu, Y; Kohno, Y; Lin, EC; Liu, SJ; Okerberg, E; Pham, L; Wu, J; Kozarich, JW Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase. Bioorg Med Chem Lett 19:4743-6 (2009) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50296837
Synonyms:
5-cyclobutyl-7-methoxy-2-(2-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)pyridin-3-yl)-4H-benzo[d][1,3]oxazin-4-one | CHEMBL559678
Type:
Small organic molecule
Emp. Form.:
C28H35N5O3
Mol. Mass.:
489.6092
SMILES:
COc1cc(C2CCC2)c2c(c1)nc(oc2=O)-c1cccnc1N1CCN(CC1)C1CCN(C)CC1
Structure:
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