Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 1
Ligand
BDBM50297742
Substrate
n/a
Meas. Tech.
ChEMBL_584048 (CHEMBL1055928)
Ki
1221±n/a nM
Citation
 Aki, C; Chao, J; Ferreira, JA; Dwyer, MP; Yu, Y; Chao, J; Merritt, RJ; Lai, G; Wu, M; Hipkin, RW; Fan, X; Gonsiorek, W; Fosseta, J; Rindgen, D; Fine, J; Lundell, D; Taveras, AG; Biju, P Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region. Bioorg Med Chem Lett 19:4446-9 (2009) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM50297742
Synonyms:
(R)-5-chloro-3-(3,4-dioxo-2-(1-(thiophen-2-yl)propylamino)cyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide | CHEMBL550880
Type:
Small organic molecule
Emp. Form.:
C20H20ClN3O4S
Mol. Mass.:
433.908
SMILES:
CC[C@@H](Nc1c(Nc2cc(Cl)cc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cccs1 |r|
Structure:
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