Reaction Details Report a problem with these data
Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50299693
Substrate
n/a
Meas. Tech.
ChEMBL_588643 (CHEMBL1056053)
IC50
6800±n/a nM
Citation
 Lv, PC; Wang, KR; Yang, Y; Mao, WJ; Chen, J; Xiong, J; Zhu, HL Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors. Bioorg Med Chem Lett 19:6750-4 (2009) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH)
Type:
Enzyme
Mol. Mass.:
33506.68
Organism:
Escherichia coli
Description:
C3TDZ2
Residue:
317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF
  
Inhibitor
Name:
BDBM50299693
Synonyms:
4-bromo-2-((2-(4-(4-chlorophenyl)thiazol-2-yl)hydrazono)methyl)phenol | CHEMBL571253
Type:
Small organic molecule
Emp. Form.:
C16H11BrClN3OS
Mol. Mass.:
408.7
SMILES:
Oc1ccc(Br)cc1CN=Nc1nc(cs1)-c1ccc(Cl)cc1 |w:9.9|
Structure:
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