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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM26673
Substrate
n/a
Meas. Tech.
ChEMBL_588650 (CHEMBL1056060)
IC50
50±n/a nM
Citation
 Abadi, AH; Abouel-Ella, DA; Lehmann, J; Tinsley, HN; Gary, BD; Piazza, GA; Abdel-Fattah, MA Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach. Eur J Med Chem 45:90-7 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM26673
Synonyms:
6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile | CHEMBL391586 | pyridone-based compound, 1
Type:
Small organic molecule
Emp. Form.:
C18H11BrN2O2
Mol. Mass.:
367.196
SMILES:
Oc1ccc(Br)cc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Structure:
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