Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCREB-binding protein/p53
LigandBDBM50229787
Substrate/Competitorn/a
Meas. Tech.ChEMBL_589613
IC50 1±n/a nM
Citation Allen, JGBourbeau, MPWohlhieter, GEBartberger, MDMichelsen, KHungate, RGadwood, RCGaston, RDEvans, BMann, LWMatison, MESchneider, SHuang, XYu, DAndrews, PSReichelt, ALong, AMYakowec, PYang, EYLee, TAOliner, JD Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J Med Chem52:7044-53 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
CREB-binding protein/p53
Name:CREB-binding protein/p53
Synonyms:Antigen NY-CO-13 | Cellular tumor antigen p53 | GST-p53 | His6-p53 | Phosphoprotein p53 | Tumor Suppressor p53
Type:fusion protein
Mol. Mass.:43654.73
Organism:Homo sapiens (Human)
Description:The full-length His6-wt-p53 expressed in E. coli was used in assays.
Residue:393
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50229787
NameBDBM50229787
Synonyms:(4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl)(piperazin-1-yl)methanone | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one | 4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one | 4-[(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one | CHEMBL191334 | NUTLIN-3 | Nutlin-3a | rac-4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
TypeSmall organic molecule
Emp. Form.C30H30Cl2N4O4
Mol. Mass.581.49
SMILESCOc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1 |t:6|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a