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TargetCREB-binding protein/p53
LigandBDBM50299822
Substrate/Competitorn/a
Meas. Tech.ChEMBL_589609
IC50 9.4±n/a nM
Citation Allen, JGBourbeau, MPWohlhieter, GEBartberger, MDMichelsen, KHungate, RGadwood, RCGaston, RDEvans, BMann, LWMatison, MESchneider, SHuang, XYu, DAndrews, PSReichelt, ALong, AMYakowec, PYang, EYLee, TAOliner, JD Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J Med Chem52:7044-53 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
CREB-binding protein/p53
Name:CREB-binding protein/p53
Synonyms:Antigen NY-CO-13 | Cellular tumor antigen p53 | GST-p53 | His6-p53 | Phosphoprotein p53 | Tumor Suppressor p53
Type:fusion protein
Mol. Mass.:43654.73
Organism:Homo sapiens (Human)
Description:The full-length His6-wt-p53 expressed in E. coli was used in assays.
Residue:393
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50299822
NameBDBM50299822
Synonyms:(+/-)-syn-6,7-Bis(4-chlorophenyl)-12-methyl-7,12-dihydro-6Hchromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine | CHEMBL584299
TypeSmall organic molecule
Emp. Form.C25H18Cl2N4O
Mol. Mass.461.343
SMILESCN1c2ncnn2C(C2=C1c1ccccc1OC2c1ccc(Cl)cc1)c1ccc(Cl)cc1 |c:9|
Structure
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n/a