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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM50299846
Substrate
n/a
Meas. Tech.
ChEMBL_589681 (CHEMBL1057686)
Ki
39±n/a nM
Citation
 Buchholz, M; Hamann, A; Aust, S; Brandt, W; Böhme, L; Hoffmann, T; Schilling, S; Demuth, HU; Heiser, U Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement. J Med Chem 52:7069-80 (2009) [PubMed]  Article 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM50299846
Synonyms:
3-[3-(5-Methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2,3,5,6,7,8,9,10-octahydrocycloocta[4,5]-thieno[2,3-d]pyrimidin-4(1H)-one | CHEMBL567842
Type:
Small organic molecule
Emp. Form.:
C19H26N4S2
Mol. Mass.:
374.567
SMILES:
Cc1cncn1CCCN1Cc2c(NC1=S)sc1CCCCCCc21
Structure:
Search PDB for entries with ligand similarity: