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Target
Elongation of very long chain fatty acids protein 6
Ligand
BDBM50299965
Substrate
n/a
Meas. Tech.
ChEMBL_592845 (CHEMBL1045788)
IC50
29±n/a nM
Citation
 Mizutani, T; Ishikawa, S; Nagase, T; Takahashi, H; Fujimura, T; Sasaki, T; Nagumo, A; Shimamura, K; Miyamoto, Y; Kitazawa, H; Kanesaka, M; Yoshimoto, R; Aragane, K; Tokita, S; Sato, N Discovery of novel benzoxazinones as potent and orally active long chain fatty acid elongase 6 inhibitors. J Med Chem 52:7289-300 (2009) [PubMed]  Article 
Target
Name:
Elongation of very long chain fatty acids protein 6
Synonyms:
ELOV6_MOUSE | Elovl6 | Face | Lce | Masr
Type:
PROTEIN
Mol. Mass.:
31624.93
Organism:
Mus musculus
Description:
ChEMBL_572244
Residue:
267
Sequence:
MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMLYILMTKGLKQSVCDQSFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVINYLVFNWMQHDNDQCYSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKVKKATKAE
  
Inhibitor
Name:
BDBM50299965
Synonyms:
4-Fluoro-N-{[(+)-2-oxo-6-(1H-pyrazol-1-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}benzamide | 4-Fluoro-N-{[2-oxo-6-(1H-pyrazol-1-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}benzamide | CHEMBL585922
Type:
Small organic molecule
Emp. Form.:
C20H14F4N4O3
Mol. Mass.:
434.3438
SMILES:
Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-n1cccn1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: