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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM50300550
Substrate
n/a
Meas. Tech.
ChEMBL_588743 (CHEMBL1053690)
IC50
104000±n/a nM
Citation
 Beausoleil, E; Chauvignac, C; Taverne, T; Lacombe, S; Pognante, L; Leblond, B; Pallares, D; Oliveira, CD; Bachelot, F; Carton, R; Peillon, H; Coutadeur, S; Picard, V; Lambeng, N; Désiré, L; Schweighoffer, F Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding. Bioorg Med Chem Lett 19:5594-8 (2009) [PubMed]  Article 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1 | RAC1_HUMAN | Ras-related C3 botulinum toxin substrate 1 | Ras-related C3 botulinum toxin substrate 1/T-lymphoma invasion and metastasis-inducing protein 1 | TC25
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1337921
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM50300550
Synonyms:
3-(3,4-Dihydroxy-phenyl)-6,7-dimethoxy-1-methyl-isoquinolinium chloride | CHEMBL574677
Type:
Small organic molecule
Emp. Form.:
C18H17NO4
Mol. Mass.:
311.3319
SMILES:
COc1cc2cc(nc(C)c2cc1OC)-c1ccc(O)c(O)c1
Structure:
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