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Target
Casein kinase I isoform delta
Ligand
BDBM50206421
Substrate
n/a
Meas. Tech.
ChEMBL_599884 (CHEMBL1045449)
IC50
230±n/a nM
Citation
 Peifer, C; Abadleh, M; Bischof, J; Hauser, D; Schattel, V; Hirner, H; Knippschild, U; Laufer, S 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta. J Med Chem 52:7618-30 (2009) [PubMed]  Article 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta)
Type:
Enzyme
Mol. Mass.:
47356.76
Organism:
Homo sapiens (Human)
Description:
P48730
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM50206421
Synonyms:
3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)isoxazole | 4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl)pyridine | 4-[3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl]pyridine | CHEMBL220227
Type:
Small organic molecule
Emp. Form.:
C17H15FN2O
Mol. Mass.:
282.3122
SMILES:
CC(C)c1onc(c1-c1ccncc1)-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: