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Targetchemokine (C-X-C motif) receptor 3
LigandBDBM50300906
Substrate/Competitorn/a
Meas. Tech.ChEMBL_600877
IC50 1.1±n/a nM
Citation Du, XGustin, DJChen, XDuquette, JMcGee, LRWang, ZEbsworth, KHenne, KLemon, BMa, JMiao, SSabalan, ESullivan, TJTonn, GCollins, TLMedina, JC Imidazo-pyrazine derivatives as potent CXCR3 antagonists. Bioorg Med Chem Lett19:5200-4 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
chemokine (C-X-C motif) receptor 3
Name:chemokine (C-X-C motif) receptor 3
Synonyms:AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3A
Type:Enzyme Catalytic Domain
Mol. Mass.:40665.65
Organism:Homo sapiens (Human)
Description:n/a
Residue:368
Sequence:
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALY
SLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFG
SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCL
LFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILA
VLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAK
SVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSET
SEASYSGL
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  Blast E-value cutoff:
BDBM50300906
NameBDBM50300906
Synonyms:CHEMBL576096 | N-{(R)-1-[3-(4-Cyano-phenyl)-8-cyclopropyl-imidazo[1,2-a]pyrazin-2-yl]-ethyl}-N-(1,1-dioxo-hexahydro-1lambda*6*-thiopyran-4-ylmethyl)-2-(4-trifluoromethoxy-phenyl)-acetamide
TypeSmall organic molecule
Emp. Form.C33H32F3N5O4S
Mol. Mass.651.698
SMILESC[C@@H](N(CC1CCS(=O)(=O)CC1)C(=O)Cc1ccc(OC(F)(F)F)cc1)c1nc2c(nccn2c1-c1ccc(cc1)C#N)C1CC1 |r|
Structure
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n/a