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Target
C-X-C chemokine receptor type 3
Ligand
BDBM50300905
Substrate
n/a
Meas. Tech.
ChEMBL_597924 (CHEMBL1042709)
IC50
13±n/a nM
Citation
 Du, X; Gustin, DJ; Chen, X; Duquette, J; McGee, LR; Wang, Z; Ebsworth, K; Henne, K; Lemon, B; Ma, J; Miao, S; Sabalan, E; Sullivan, TJ; Tonn, G; Collins, TL; Medina, JC Imidazo-pyrazine derivatives as potent CXCR3 antagonists. Bioorg Med Chem Lett 19:5200-4 (2009) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
CXCR3_MOUSE | Cmkar3 | Cxcr3
Type:
PROTEIN
Mol. Mass.:
41020.84
Organism:
Mus musculus
Description:
ChEMBL_560734
Residue:
367
Sequence:
MYLEVSERQVLDASDFAFLLENSTSPYDYGENESDFSDSPPCPQDFSLNFDRTFLPALYSLLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLVLTLPLWAVDAAVQWVFGPGLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATQIYRRDPRVRVALTCIVVWGLCLLFALPDFIYLSANYDQRLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRFRAMRLVVVVVAAFAVCWTPYHLVVLVDILMDVGVLARNCGRESHVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFREQMWMLFTRLGRSDQRGPQRQPSSSRRESSWSETTEASYLGL
  
Inhibitor
Name:
BDBM50300905
Synonyms:
CHEMBL578192 | N-{(R)-1-[3-(4-Cyano-phenyl)-8-cyclopropyl-imidazo[1,2-a]pyrazin-2-yl]-ethyl}-N-(1,1-dioxo-hexahydro-1lambda*6*-thiopyran-4-ylmethyl)-2-(3-fluoro-4-trifluoromethyl-phenyl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C33H31F4N5O3S
Mol. Mass.:
653.69
SMILES:
C[C@@H](N(CC1CCS(=O)(=O)CC1)C(=O)Cc1ccc(c(F)c1)C(F)(F)F)c1nc2c(nccn2c1-c1ccc(cc1)C#N)C1CC1 |r|
Structure:
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