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Targetchemokine (C-X-C motif) receptor 3
LigandBDBM50229439
Substrate/Competitorn/a
Meas. Tech.ChEMBL_600877
IC50 0.7±n/a nM
Citation Du, XGustin, DJChen, XDuquette, JMcGee, LRWang, ZEbsworth, KHenne, KLemon, BMa, JMiao, SSabalan, ESullivan, TJTonn, GCollins, TLMedina, JC Imidazo-pyrazine derivatives as potent CXCR3 antagonists. Bioorg Med Chem Lett19:5200-4 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
chemokine (C-X-C motif) receptor 3
Name:chemokine (C-X-C motif) receptor 3
Synonyms:AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3A
Type:Enzyme Catalytic Domain
Mol. Mass.:40665.65
Organism:Homo sapiens (Human)
Description:n/a
Residue:368
Sequence:
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALY
SLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFG
SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCL
LFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILA
VLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAK
SVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSET
SEASYSGL
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BDBM50229439
NameBDBM50229439
Synonyms:(R)-N-(1-(1-(4-cyanophenyl)-4-phenyl-1H-imidazol-2-yl)ethyl)-N-(2-(ethylsulfonyl)ethyl)-2-(4-fluoro-3-(trifluoromethyl)phenyl)acetamide | CHEMBL403036
TypeSmall organic molecule
Emp. Form.C31H28F4N4O3S
Mol. Mass.612.638
SMILESCCS(=O)(=O)CCN([C@H](C)c1nc(cn1-c1ccc(cc1)C#N)-c1ccccc1)C(=O)Cc1ccc(F)c(c1)C(F)(F)F
Structure
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n/a