Target
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Ligand
BDBM50300952
Substrate
n/a
Meas. Tech.
ChEMBL_597960 (CHEMBL1042745)
IC50
15±n/a nM
Citation
 Hughes, ROWalker, JKRogier, DJHeasley, SEBlevis-Bal, RMBenson, AGJacobsen, EJCubbage, JWFobian, YMOwen, DRFreskos, JNMolyneaux, JMBrown, DLAcker, BAMaddux, TMTollefson, MBMoon, JBMischke, BVRumsey, JMZheng, YMacInnes, ABond, BRYu, Y Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one. Bioorg Med Chem Lett 19:5209-13 (2009) [PubMed]  Article 
Target
Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Synonyms:
PDE6A | PDE6A_HUMAN | PDEA | Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha
Type:
PROTEIN
Mol. Mass.:
99531.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1347866
Residue:
860
Sequence:
MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEIIFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAVLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILASPIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGNQPGGNPSPGGATTSKSCCIQ
  
Inhibitor
Name:
BDBM50300952
Synonyms:
3-(trans-4-hydroxycyclohexylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2(1H)-one | CHEMBL566820
Type:
Small organic molecule
Emp. Form.:
C24H31N5O4
Mol. Mass.:
453.534
SMILES:
CCCOCCn1c2cc(cnc2nc(N[C@H]2CC[C@H](O)CC2)c1=O)-c1ccc(OC)nc1 |r,wU:16.16,wD:19.20,(3.98,.08,;2.65,-.69,;2.65,-2.23,;1.32,-3,;1.32,-4.54,;-.02,-5.31,;-.02,-6.85,;1.31,-7.63,;2.64,-6.86,;3.96,-7.62,;3.97,-9.17,;2.64,-9.93,;1.31,-9.17,;-.02,-9.93,;-1.36,-9.16,;-2.7,-9.93,;-4.03,-9.15,;-5.37,-9.93,;-6.7,-9.15,;-6.69,-7.6,;-8.02,-6.82,;-5.35,-6.84,;-4.03,-7.62,;-1.35,-7.63,;-2.68,-6.86,;5.29,-6.85,;6.63,-7.62,;7.96,-6.84,;7.95,-5.3,;9.28,-4.53,;10.62,-5.29,;6.61,-4.54,;5.28,-5.31,)|
Structure:
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