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Target
Urokinase-type plasminogen activator
Ligand
BDBM50302000
Substrate
n/a
Meas. Tech.
ChEMBL_599341 (CHEMBL1042862)
IC50
>30000±n/a nM
Citation
 West, CW; Adler, M; Arnaiz, D; Chen, D; Chu, K; Gualtieri, G; Ho, E; Huwe, C; Light, D; Phillips, G; Pulk, R; Sukovich, D; Whitlow, M; Yuan, S; Bryant, J Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA). Bioorg Med Chem Lett 19:5712-5 (2009) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator/surface receptor
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50302000
Synonyms:
4-(dimethylamino)-2-(6-(3'-((dimethylamino)methyl)biphenyl-3-yloxy)-3,5-difluoropyridin-2-yloxy)benzoic acid | CHEMBL569576
Type:
Small organic molecule
Emp. Form.:
C29H27F2N3O4
Mol. Mass.:
519.5392
SMILES:
CN(C)Cc1cccc(c1)-c1cccc(Oc2nc(Oc3cc(ccc3C(O)=O)N(C)C)c(F)cc2F)c1
Structure:
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