Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50303015
Substrate
n/a
Meas. Tech.
ChEMBL_596964 (CHEMBL1038201)
IC50
4.91±n/a nM
Citation
 Lee, SH; Seo, HJ; Kim, MJ; Kang, SY; Lee, SH; Ahn, K; Lee, M; Han, HK; Kim, J; Lee, J Pentacycle derivatives as cannabinoid CB1 receptor ligands. Bioorg Med Chem Lett 19:6632-6 (2009) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52856.55
Organism:
Rattus norvegicus (rat)
Description:
P20272
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50303015
Synonyms:
2-(5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-pyrazol-3-yl)-5-(1-(4-chlorophenyl)cyclopropyl)-1,3,4-oxadiazole | CHEMBL578200
Type:
Small organic molecule
Emp. Form.:
C29H18BrCl3N6O2
Mol. Mass.:
668.755
SMILES:
Cc1nnc(o1)-c1c(nn(c1-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl)-c1nnc(o1)C1(CC1)c1ccc(Cl)cc1
Structure:
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