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Target
Cathepsin Z
Ligand
BDBM50303417
Substrate
n/a
Meas. Tech.
ChEMBL_595889 (CHEMBL1040869)
IC50
3162.28±n/a nM
Citation
 Mott, BT; Ferreira, RS; Simeonov, A; Jadhav, A; Ang, KK; Leister, W; Shen, M; Silveira, JT; Doyle, PS; Arkin, MR; McKerrow, JH; Inglese, J; Austin, CP; Thomas, CJ; Shoichet, BK; Maloney, DJ Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem 53:52-60 (2010) [PubMed]  Article 
Target
Name:
Cathepsin Z
Synonyms:
CATZ_HUMAN | CTSZ | Cathepsin P | Cathepsin X
Type:
PROTEIN
Mol. Mass.:
33870.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_595889
Residue:
303
Sequence:
MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV
  
Inhibitor
Name:
BDBM50303417
Synonyms:
4-(Cyclopentylamino)-6-(3,5-difluorophenylamino)-1,3,5-triazine-2-carbonitrile | CHEMBL568171
Type:
Small organic molecule
Emp. Form.:
C15H14F2N6
Mol. Mass.:
316.3087
SMILES:
Fc1cc(F)cc(Nc2nc(NC3CCCC3)nc(n2)C#N)c1
Structure:
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