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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50303596
Substrate
n/a
Meas. Tech.
ChEMBL_596266 (CHEMBL1050682)
IC50
140±n/a nM
Citation
 Klüter, S; Grütter, C; Naqvi, T; Rabiller, M; Simard, JR; Pawar, V; Getlik, M; Rauh, D Displacement assay for the detection of stabilizers of inactive kinase conformations. J Med Chem 53:357-67 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50303596
Synonyms:
CHEMBL566100 | N-(4-(3-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)phenylamino)quinolin-6-yl)propionamide
Type:
Small organic molecule
Emp. Form.:
C33H35N7O2
Mol. Mass.:
561.6767
SMILES:
CCC(=O)Nc1ccc2nccc(Nc3cccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c3)c2c1
Structure:
Search PDB for entries with ligand similarity: