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Target
Egl nine homolog 1
Ligand
BDBM50303765
Substrate
n/a
Meas. Tech.
ChEMBL_597531 (CHEMBL1047006)
IC50
21±n/a nM
Citation
 Leung, IK; Flashman, E; Yeoh, KK; Schofield, CJ; Claridge, TD Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions. J Med Chem 53:867-75 (2010) [PubMed]  Article 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM50303765
Synonyms:
2-(3-hydroxy-2-((naphthalen-2-ylsulfonyl)carbonylimino)-2,3-dihydrothiazol-4-yl)acetic acid | CHEMBL570655
Type:
Small organic molecule
Emp. Form.:
C16H12N2O6S2
Mol. Mass.:
392.406
SMILES:
OC(=O)Cc1cs\c(=N/C(=O)S(=O)(=O)c2ccc3ccccc3c2)n1O
Structure:
Search PDB for entries with ligand similarity: