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Target
Mu-type opioid receptor
Ligand
BDBM50303852
Substrate
n/a
Meas. Tech.
ChEMBL_594975 (CHEMBL1038966)
Ki
0.300000±n/a nM
Citation
 Hsin, LW; Chang, LT; Rothman, RB; Dersch, CM; Fishback, JA; Matsumoto, RR Synthesis and opioid activity of enantiomeric N-substituted 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolines. J Med Chem 53:1392-6 (2010) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50303852
Synonyms:
(+)-trans-3-(2-Phenylethyl)-2,3,4,4aalpha,5,6,7,7aalpha-octahydro-1Hbenzo[4,5]furo[3,2-e]isoquinolin-9-ol | (-)-trans-3-(2-Phenylethyl)-2,3,4,4aalpha,5,6,7,7aalpha-octahydro-1Hbenzo[4,5]furo[3,2-e]isoquinolin-9-ol | CHEMBL585721
Type:
Small organic molecule
Emp. Form.:
C23H27NO2
Mol. Mass.:
349.466
SMILES:
Oc1cccc2c1O[C@H]1CCC[C@H]3CN(CCc4ccccc4)CC[C@]213 |r|
Structure:
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