Reaction Details Report a problem with these data
Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50303868
Substrate
n/a
Meas. Tech.
ChEMBL_595158 (CHEMBL1037323)
IC50
2000±n/a nM
Citation
 Dang, Q; Kasibhatla, SR; Xiao, W; Liu, Y; Dare, J; Taplin, F; Reddy, KR; Scarlato, GR; Gibson, T; van Poelje, PD; Potter, SC; Erion, MD Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics. J Med Chem 53:441-51 (2010) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_RAT | Fbp | Fbp1 | Fructose-1,6-bisphosphatase
Type:
PROTEIN
Mol. Mass.:
39605.40
Organism:
Rattus norvegicus
Description:
ChEMBL_595158
Residue:
363
Sequence:
MVDHAPFETDISTLTRFVLEEGRKAGGTGEMTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEEDTHAIIIEPEKRGKYVVCFDPLDGSSNIDCLASIGTIFGIYRKTSANEPSEKDALQPGRNLVAAGYALYGSATMLVLAMNCGVNCFMLDPSIGEFILVDRDVKIKKKGNIYSINEGYAKDFDPAINEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKNPSGKLRLLYECNPIAYVMEKAGGLATTGNEDILDIVPTEIHQKAPVIMGSTEDVQEFLEIYNKDKAKSRPSLPLPQSRARESPVHSICDELF
  
Inhibitor
Name:
BDBM50303868
Synonyms:
4-Amino-5-fluoro-6-chloro-1-isobutyl-2-[5-(2-phosphono)furanyl]-benzimidazole | CHEMBL571183
Type:
Small organic molecule
Emp. Form.:
C15H16ClFN3O4P
Mol. Mass.:
387.73
SMILES:
CC(C)Cn1c(nc2c(N)c(F)c(Cl)cc12)-c1ccc(o1)P(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: