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Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50304140
Substrate
n/a
Meas. Tech.
ChEMBL_602349 (CHEMBL1041579)
Ki
100±n/a nM
Citation
 Hocková, D; Holý, A; Masojídková, M; Keough, DT; de Jersey, J; Guddat, LW Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorg Med Chem 17:6218-32 (2009) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM50304140
Synonyms:
9-[2-(1-Phosphonopropan-2-yloxy)ethyl]guanine | CHEMBL594335
Type:
Small organic molecule
Emp. Form.:
C10H16N5O5P
Mol. Mass.:
317.2383
SMILES:
CC(CP(O)(O)=O)OCCn1cnc2c1nc(N)[nH]c2=O
Structure:
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