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Target
Endothelin-1 receptor
Ligand
BDBM50304498
Substrate
n/a
Meas. Tech.
ChEMBL_603857 (CHEMBL1046474)
Ki
2.43±n/a nM
Citation
 Höltke, C; Law, MP; Wagner, S; Kopka, K; Faust, A; Breyholz, HJ; Schober, O; Bremer, C; Riemann, B; Schäfers, M PET-compatible endothelin receptor radioligands: synthesis and first in vitro and in vivo studies. Bioorg Med Chem 17:7197-208 (2009) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_MOUSE | Ednra | Endothelin receptor ET-A | Gpcr10
Type:
PROTEIN
Mol. Mass.:
48591.87
Organism:
Mus musculus
Description:
ChEMBL_723169
Residue:
427
Sequence:
MSIFCLAAYFWLTMVGGVMADNPERYSANLSSHMEDFTPFPGTEINFLGTTHRPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGELHRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50304498
Synonyms:
3-Benzo[1,3]dioxol-5-yl-5-[4-(2-fluoroethoxy)phenyl]-5-hydroxy-4-(3,4,5-trimethoxybenzyl)-5H-furan-2-one | CHEMBL604286
Type:
Small organic molecule
Emp. Form.:
C29H27FO9
Mol. Mass.:
538.5177
SMILES:
COc1cc(CC2=C(C(=O)OC2(O)c2ccc(OCCF)cc2)c2ccc3OCOc3c2)cc(OC)c1OC |t:6|
Structure:
Search PDB for entries with ligand similarity: