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Target
Endothelin receptor type B
Ligand
BDBM50034267
Substrate
n/a
Meas. Tech.
ChEMBL_603858 (CHEMBL1046475)
IC50
780±n/a nM
Citation
 Höltke, C; Law, MP; Wagner, S; Kopka, K; Faust, A; Breyholz, HJ; Schober, O; Bremer, C; Riemann, B; Schäfers, M PET-compatible endothelin receptor radioligands: synthesis and first in vitro and in vivo studies. Bioorg Med Chem 17:7197-208 (2009) [PubMed]  Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB_MOUSE | ET-B | ET-BR | Ednrb | Endothelin B receptor | Endothelin receptor non-selective type
Type:
PROTEIN
Mol. Mass.:
49587.98
Organism:
Mus musculus
Description:
ChEMBL_603858
Residue:
442
Sequence:
MQSPASRCGRALVALLLACGFLGVWGEKRGFPPAQATLSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRGAGVPPRSFPPPCQRNIEISKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINTYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDMITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAVFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPHRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50034267
Synonyms:
3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-(3,4,5-trimethoxybenzyl)furan-2(5H)-one | 3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phenyl)-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one | CHEMBL8981 | PD-156707 | PD156707
Type:
Small organic molecule
Emp. Form.:
C28H26O9
Mol. Mass.:
506.5006
SMILES:
COc1ccc(cc1)C1(O)OC(=O)C(=C1Cc1cc(OC)c(OC)c(OC)c1)c1ccc2OCOc2c1 |c:14|
Structure:
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